〔Abstract〕 Serine is a non-essential amino acid that plays a key role in the synthesis of biomolecules such as pro- teins , nucleotides and lipids , and changes in the uptake , absorption , synthesis and catabolic levels of serine in vi- vo all affect multiple physiological processes in tissue cells . Serine plays a key role in intracellular energy metabo- lism and signaling linkages , and has a profound impact on the developmental processes of a variety of metabolic dis- eases , cancer , neurodegenerative diseases and aging. In-depth study of serine metabolic pathways can provide new targets and strategies for early diagnosis , treatment and prevention of related diseases . Based on the physiological function of serine , this article expounds the synthetic and metabolic transformation of serine in cells , and reviews the research progress of intracellular serine metabolism on cell physiology and related diseases at home and abroad , which provides a theoretical reference for serine metabolism as an emerging target for disease treatment.